CCL22 Recruits CD4-positive CD25-positive Regulatory T Cells into Malignant Pleural Effusion
نویسندگان
چکیده
منابع مشابه
CCL22 recruits CD4-positive CD25-positive regulatory T cells into malignant pleural effusion.
PURPOSE The aim of this study was to explore the presence of the chemokines CCL22 and CCL17 in malignant pleural effusion, and the chemoattractant activity of these chemokines on CD4-positive CD25-positive Foxp3-positive regulatory T cells infiltrating into the pleural space. EXPERIMENTAL DESIGN The concentrations of CCL22 and CCL17 in both pleural effusions and sera from 33 patients with lun...
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The CD4+ CD25+ regulatory T cells play a critical role in controlling autoimmunity, but little is known about their development and maintenance. In this study, we investigated whether CD4+ CD25- cells can convert to CD4+ CD25+ regulatory T cells in vivo under natural conditions. CD4+ CD25- cells from CD45.1+ mice were sorted and transferred into congenic CD45.2+ mice. Converted CD4+ CD25+ cells...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2009
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-08-2641